No Association between Progesterone Receptor Gene +331G/A Polymorphism and Endometrial Cancer
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چکیده
منابع مشابه
No association between progesterone receptor gene +331G/A polymorphism and endometrial cancer.
The major hypothesis proposed to explain endometrial cancer risk is the unopposed estrogen hypothesis which states that elevated levels of plasma estrogens not counterbalanced by high levels of plasma progesterone increase risk of endometrial cancer (1-3). The action of progesterone on the endometrium is mediated by the progesterone receptor (hPR) that exists in two different forms (hPR-A and h...
متن کاملNo association between the progesterone receptor gene +331G/A polymorphism and breast cancer.
Progesterone is critical to normal breast development, and its activity is mediated by the progesterone receptor (PR) that is part of the steroid-thyroid-retinoic acid receptor superfamily of transcription factors (1). A single copy of the progesterone receptor gene (PGR), located on chromosome 11q22-23, uses separate promoters and translation start sites to produce two protein isoforms, PR-A a...
متن کاملNull Results in Brief No Association between the Progesterone Receptor Gene +331G/A Polymorphism and Breast Cancer
Progesterone is critical to normal breast development, and its activity is mediated by the progesterone receptor (PR) that is part of the steroid-thyroid-retinoic acid receptor superfamily of transcription factors (1). A single copy of the progesterone receptor gene (PGR), located on chromosome 11q22-23, uses separate promoters and translation start sites to produce two protein isoforms, PR-A a...
متن کاملNo association between EGF gene polymorphism and gastric cancer.
The etiology of gastric cancer is not well-understood. Epidermal growth factor (EGF) transduces growth signals to mitogen-activated protein kinase via RAS and BRAF, and EGF/EGF receptor interaction is important for tumor growth and progression. Previous studies have reported that the EGF +61 (A/G) single nucleotide polymorphism in the 5'-untranslated region of the EGF gene is functional, and is...
متن کاملAssociation of Alu Insertion Polymorphism in Progesterone Receptor Gene with Risk of Multiple Sclerosis
Background and purpose: Multiple sclerosis (MS) is a chronic autoimmune disease in which the myelin sheaths of nerve cells in the brain and spinal cord are damaged. The prevalence of disease is higher in women and it seems that sex hormones, which usually exert their effects through receptors, are involved in susceptibility to MS. Considering the functional role of Alu insertion 306 bp polymorp...
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ژورنال
عنوان ژورنال: Cancer Epidemiology Biomarkers & Prevention
سال: 2006
ISSN: 1055-9965,1538-7755
DOI: 10.1158/1055-9965.epi-06-0215